Key result
Angiopoietin-2 plasma levels above 15 µg/mL at admission were associated with a significantly increased risk of 7-day mortality (OR 13.3) in medical-ward patients with SIRS or sepsis.
Why the study?
Does Angiopoietin-2 plasma level predict early mortality and organ dysfunction in medical-ward patients with SIRS/sepsis?
Cross-Sectional (n=80)
Blinded to biomarker results
No
Does Angiopoietin-2 plasma level predict early mortality and organ dysfunction in medical-ward patients with SIRS/sepsis?
Elevated Angiopoietin-2 plasma levels (>15 µg/mL) at admission are predictive of early mortality and organ dysfunction in medical-ward patients with SIRS/sepsis.
Answers are grounded in this paper and cite their sources.
May inform early risk stratification in ward sepsis; hypothesis-generating and requires prospective validation before clinical adoption.
Background: SIRS/sepsis accounts for vast majority of deaths in ICU a medical ward department. More than 650,000 cases of sepsis are diagnosed in the United States annually, with 30-50% mortality and individually cost more than 22,000 dollars.
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Marina De Roia (2013) conducted a cross-sectional in SIRS/Sepsis (n=80). Angiopoietin-2 (Ang-2) plasma levels > 15 µg/mL vs. Angiopoietin-2 (Ang-2) plasma levels ≤ 15 µg/mL was evaluated on 7-day mortality (OR 13.3, 95% CI 2.6-71). Angiopoietin-2 plasma levels above 15 µg/mL at admission were associated with a significantly increased risk of 7-day mortality (OR 13.3) in medical-ward patients with SIRS or sepsis.
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