Key result
Severe sepsis was associated with significantly increased serum Ang-2 levels compared to no SIRS or sepsis (P<0.05), correlating positively with TNF-alpha and disease severity scores.
Population
61 critically-ill patients grouped by septic stage: no systemic inflammatory response syndrome, systemic…
Design
Cohort
Authors
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Serum Ang-2 may mark sepsis severity; leaves open causal role and therapeutic utility.
Observational (n=61)
No
p-value: p=<.05
Serum Ang-2 levels are elevated in severe sepsis and correlate with disease severity and inflammatory mediators like TNF-alpha, though human lung endothelium may not be the primary source.
Orfanos et al. (2006) conducted an observational in Sepsis (n=61). Severe sepsis vs. No systemic inflammatory response syndrome (SIRS) or sepsis was evaluated on Serum Angiopoietin-2 (Ang-2) levels (p=<.05). Severe sepsis was associated with significantly increased serum Ang-2 levels compared to no SIRS or sepsis (P<0.05), correlating positively with TNF-alpha and disease severity scores.
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