Key result
PPARγ expression in the aorta and left ventricle showed poor predictive value for the development of heart failure after CABG (AUC 0.531 and 0.540, respectively).
Why the study?
Does PPARγ expression in the aorta and left ventricle predict the development of heart failure in patients with CAD after CABG?
Cohort (n=157)
Does PPARγ expression in the aorta and left ventricle predict the development of heart failure in patients with CAD after CABG?
Effect estimate: AUC 0.531 (95% CI 0.442-0.619)
PPARγ expression in the aorta and left ventricle during CABG does not reliably predict the subsequent development of heart failure.
No takes yet. Share an insight, caveat, or question.
PPARγ expression should not guide post-CABG HF risk assessment; leaves open whether other PPAR targets influence outcomes in CAD.
Wojtkowska et al. (2014) conducted a cohort in Coronary artery disease (CAD) after coronary artery bypass-grafting (CABG) (n=157). PPARγ expression in aorta and left ventricle was evaluated on Development of heart failure (LVEF <40% or NT-proBNP >400 pg/mL or 6MWT <400 m) (AUC 0.531, 95% CI 0.442-0.619). PPARγ expression in the aorta and left ventricle showed poor predictive value for the development of heart failure after CABG (AUC 0.531 and 0.540, respectively).
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