What is the clinical evidence from this study?

Study design: Observational. Population: End-stage heart failure due to ischemic cardiomyopathy (n=9). Intervention: Ischemic cardiomyopathy vs. Non-failing donor hearts. Primary outcome: PPAR-alpha and PPAR-gamma activation (p=<0.05).

September 27, 2005European Journal of Heart Failure

Activation of Peroxisome Proliferator-Activated Receptor-α and -γ in Auricular Tissue from Heart Failure Patients

Q: What are the key findings of this study?

PPAR-alpha and PPAR-gamma were selectively activated in the atria of patients with ischemic cardiomyopathy compared to non-failing atria and failing ventricles (P<0.05).

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Key result

PPAR-alpha and PPAR-gamma were selectively activated in the atria of patients with ischemic cardiomyopathy compared to non-failing atria and failing ventricles (P<0.05).

Authors

DGDulcenombre Gómez‐GarréPreventive Cardiology MHM. De la Puente HerraizInstitute for Atherosclerosis Research MGMa Luisa González‐RubioHospital Clínico San Carlos

Discussion

Member takes

Implication

Hypothesis-generating for atrial PPAR activation in ischemic cardiomyopathy; does not support clinical practice changes.

Study Design

Type

Observational (n=9)

PICO

Population

Cardiac biopsies from patients with end-stage heart failure due to ischemic cardiomyopathy and non-failing donor hearts (n=9).

Exposure / Comparator

Ischemic cardiomyopathy vs Non-failing donor hearts

Primary Outcome

PPAR-alpha and PPAR-gamma activation, p=<0.05

Main Result

p-value: p=<0.05

Cite This Study

Gómez‐Garré et al. (2005) conducted an observational in End-stage heart failure due to ischemic cardiomyopathy (n=9). Ischemic cardiomyopathy vs. Non-failing donor hearts was evaluated on PPAR-alpha and PPAR-gamma activation (p=<0.05). PPAR-alpha and PPAR-gamma were selectively activated in the atria of patients with ischemic cardiomyopathy compared to non-failing atria and failing ventricles (P<0.05).

synapsesocial.com/papers/6a7dbc48c108c8d3ff0456a6 https://doi.org/10.1016/j.ejheart.2005.06.002

Topics

Heart failure HFrEF treatment Women and heart disease

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Activation of Peroxisome Proliferator-Activated Receptor-α and -γ in Auricular Tissue from Heart Failure Patients

Discussion

Member takes

Implication

Study Design

PICO

Main Result

Cite This Study

Topics

Activation of Peroxisome Proliferator-Activated Receptor-α and -γ in Auricular Tissue from Heart Failure Patients

Discussion

Member takes

Implication

Study Design

PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider