Ring a ring o'azoles: The aza-Wittig cyclization of amino acids and peptides is extremely mild, selective, and versatile. The reaction of amino acid esters and amino acid thioester azides delivers peptidic 1,3-azolines and 1,3-azoles with unsurpassed functional-group tolerance. This method allows multiple ring closures and tolerates aqueous solvents.
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Riedrich et al. (2007) studied this question.
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