Key result
Carotid-femoral pulse wave velocity was significantly higher in hypertensive subjects with hyperuricemia (11.78 m/s) compared to those with hypertension alone (10.52 m/s), and serum uric acid was an independent associating factor.
Why the study?
Arterial stiffness characterizes hypertension and serum uric acid is involved in hypertension development, prompting investigation of the relationship between carotid-femoral pulse wave velocity and serum uric acid in hypertension and hyperuricemia.
Cross-Sectional (n=651)
No
Serum uric acid is an independent associating factor of carotid-femoral pulse wave velocity, suggesting a link between hyperuricemia and increased arterial stiffness in hypertensive patients.
Answers are grounded in this paper and cite their sources.
Hyperuricemia was associated with greater arterial stiffness in hypertension; leaves open causal role and need for prospective trials.
Increasing of arterial stiffness is the pathophysiological characteristic of hypertension. Carotid-femoral pulse wave velocity (CF-PWV) is an index of arterial stiffness. Serum uric acid has been found to be involved the development of hypertension. We investigated the relationship between CF-PWV and serum uric acid in subjects with hypertension and hyperuricemia. 651 subjects (M/F 271/380) were divided into four groups, group 1: subjects without hypertension and hyperuricemia; group 2: hypertension subjects without hyperuricemia; group 3: hyperuricemia subjects without hypertension; group 4: subjects with hypertension and hyperuricemia. CF-PWV was measured by Complior apparatus. Results showed that levels of CF-PWV (10.75 ± 2.03 vs. 10.06 ± 1.98 m/s, p < 0.001) and serum uric acid (319.33 ± 80.12 vs. 298.78 ± 74.88 umol/L, p = 0.001) were significantly higher in hypertensive (groups 2 + 4) group than in normotensive (groups 1 + 3) group. CF-PWV was significantly higher in group 4 than group 1, group 2 and group 3 (ANOVA analysis: F = 13.348, p < 0.001; 11.78 ± 2.10 vs. 9.98 ± 1.98, 10.52 ± 1.93, 10.56 ± 1.99 m/s, all p < 0.05, respectively). There was positive correlation between CF-PWV and serum uric acid in entire study group (r = 0.187, p < 0.001), even after adjusting for gender, body mass index, systolic blood pressure (SBP) and diastolic blood pressure (r = 0.100, p = 0.015). Multiple linear regressions showed that SBP, age, benzbromarone, statin and serum uric acid were independent associating factors of CFPWV in all subjects (β = 0.310, p < 0.001; β = 0.330, p < 0.001; β = 0.172, p = 0.002; β = -0.143, p = 0.006; β = 0.126, p = 0.027; respectively). In conclusions, CF-PWV was significantly higher in hypertension subjects with hyperuricemia compared to hypertension without hyperuricemia subjects, and serum uric acid was an independent associating factor of CF-PWV.
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Liu et al. (2019) conducted a cross-sectional in Hypertension and Hyperuricemia (n=651). Hyperuricemia in the presence of hypertension vs. Hypertension without hyperuricemia was evaluated on Carotid-femoral pulse wave velocity (CF-PWV) (p=<0.05). Carotid-femoral pulse wave velocity was significantly higher in hypertensive subjects with hyperuricemia (11.78 m/s) compared to those with hypertension alone (10.52 m/s), and serum uric acid was an independent associating factor.
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