Key result
Obesity in adolescents was associated with deteriorated cardiovascular parameters compared to lean controls, and pediatric metabolic syndrome criteria had low sensitivity for screening.
Why the study?
Are there risk-related cardiovascular changes in metabolically healthy obese adolescents compared to lean healthy subjects?
Cross-Sectional (n=231)
Are there risk-related cardiovascular changes in metabolically healthy obese adolescents compared to lean healthy subjects?
Obese adolescents, even when classified as metabolically healthy by IDF criteria, exhibit significant cardiovascular deterioration, suggesting current metabolic syndrome criteria are insufficiently sensitive for cardiovascular risk screening.
Answers are grounded in this paper and cite their sources.
Supports cardiovascular monitoring in obese adolescents beyond metabolic syndrome classification; leaves open optimal screening strategies pending prospective data.
Introduction Pediatric obesity reflects a real crisis for public health as associated with cardiovascular risk in subjects with developed metabolic syndrome . Simultaneously the information concerning risk related cardiovascular changes in metabolically healthy obese adolescents is pretty insufficient. Aim This study is designed to determine the risk related cardiovascular changes in metabolically healthy obese adolescents. Material and methods 208 obese adolescents were grouped as metabolically healthy and metabolically unhealthy by International Diabetes Federation (IDF) criteria for pediatric metabolic syndrome . We analyzed the basic metabolic parameters, left ventricular geometry and function, 24-hours blood pressure monitoring and carotid intima-media thickness. Control group consisted of 23 lean healthy subjects. Results and discussion 69% of obese adolescents could be considered as metabolically healthy by pediatric IDF criteria. BMI in metabolically unhealthy was greater vs. metabolically healthy ( P = 0.019) as well as dyslipidemia and dysglicemia. Cardiovascular parameters were deteriorated in all obese vs. lean healthy (myocardial hypertrophy and dysfunction, thickening of carotid vessels and systolic hypertension). It established low sensitivity (0.28) and low negative predictive value (0.29) of metabolic syndrome criteria to screen obesity associated cardiovascular problems. Conclusions Prognostic capability of pediatric metabolic syndrome criteria is pretty low due to its sensitivity. Therefore obese adolescents not met diagnostic level for metabolic syndrome by IDF criteria could be falsely excluded from the cardiovascular risk group. Thus, it is not possible to assert an existence of absolutely healthy metabolic profile in obese and more sensitive markers are necessary for the metabolically healthy obesity identification.
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Tetyana Chaychenko (2016) conducted a cross-sectional in Pediatric obesity (n=231). Obesity vs. Lean healthy subjects was evaluated on Cardiovascular parameters (myocardial hypertrophy and dysfunction, thickening of carotid vessels and systolic hypertension). Obesity in adolescents was associated with deteriorated cardiovascular parameters compared to lean controls, and pediatric metabolic syndrome criteria had low sensitivity for screening.
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