Key result
Cardiac autonomic function, measured by the Valsalva index and respiratory sinus arrhythmia, was significantly correlated with left ventricular ejection fraction (rho=0.358 and rho=0.391, respectively; p<0.001).
Why the study?
Is autonomic function associated with left ventricular systolic function in Chagas heart disease patients undergoing treatment for heart failure?
Cross-Sectional (n=118)
Is autonomic function associated with left ventricular systolic function in Chagas heart disease patients undergoing treatment for heart failure?
Effect estimate: rho 0.358
p-value: p=<0.001
Impairment of left ventricular function is directly associated with a reduction of cardiac autonomic modulation in patients with Chagas disease.
Supports autonomic assessment in Chagas HF; hypothesis-generating for progression prediction and targeted interventions.
INTRODUCTION: The association between cardiac autonomic and left ventricular (LV) dysfunction in Chagas disease (ChD) is controversial. METHODS: A standardized protocol that includes the Valsalva maneuver, a respiratory sinus arrhythmia (RSA) test, and an echocardiographic examination was used. Spearman correlation coefficients (rho) were used to investigate associations. RESULTS: The study population consisted of 118 ChD patients undergoing current medical treatment, with an average LV ejection fraction of 51.4±2.6%. The LV ejection fraction and diastolic dimension were correlated with the Valsalva index (rho=0.358, p<0.001 and rho=-0.266, p=0.004, respectively) and the RSA (rho=0.391, p<0.001 and rho=-0.311, p<0.001, respectively). CONCLUSIONS: The impairment of LV function is directly associated with a reduction of cardiac autonomic modulation in ChD.
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Raadschilders et al. (2014) conducted a cross-sectional in Chagas heart disease (n=118). Cardiac autonomic function (Valsalva index and respiratory sinus arrhythmia) was evaluated on Correlation between left ventricular ejection fraction and cardiac autonomic function (rho 0.358, p=<0.001). Cardiac autonomic function, measured by the Valsalva index and respiratory sinus arrhythmia, was significantly correlated with left ventricular ejection fraction (rho=0.358 and rho=0.391, respectively; p<0.001).
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