Key result
A positive MGCFT for Trypanosoma cruzi antibodies in pregnant women was associated with a twofold increase in the risk of pregnancy loss compared to seronegative women.
Why the study?
Does the presence of antibodies to Trypanosoma cruzi increase the risk of adverse pregnancy outcomes and maternal morbidity in pregnant women?
Observational (n=604)
Does the presence of antibodies to Trypanosoma cruzi increase the risk of adverse pregnancy outcomes and maternal morbidity in pregnant women?
Answers are grounded in this paper and cite their sources.
Maternal Trypanosoma cruzi infection is associated with a twofold increased risk of pregnancy loss and higher rates of specific maternal complications.
Pregnancy outcome and maternal morbidity were analysed in 302 pregnant women with positive Machado-Guerreiro Complement Fixation Test (MGCFT) for antibodies to Trypanosoma cruzi and 302 women with a negative MGCFT resident of Córdoba, Argentina. A comparison of positive and negative cases was employed to investigate the association between MGCFT reaction and pregnancy outcome assessed from abortion and perinatal infant mortality rates; similarly, the data were analysed for demographic and socio-economic factors, numbers of previous pregnancies (birth order) and maternal complications. A twofold increase in the risk of pregnancy loss associated with a positive MGCFT was found. The incidence of polyhydramnios and varicosities of the leg was significantly higher in the serologically reactive group.
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Hernandez-Matheson et al. (1983) conducted an observational in Trypanosoma cruzi infection in pregnancy (n=604). Positive MGCFT for Trypanosoma cruzi antibodies vs. Negative MGCFT was evaluated on Pregnancy loss (abortion and perinatal infant mortality) (twofold increase in risk). A positive MGCFT for Trypanosoma cruzi antibodies in pregnant women was associated with a twofold increase in the risk of pregnancy loss compared to seronegative women.
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