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A systematic survey of conditions and substrates for the formation of 2,4,4-trisubstituted thiazoline rings is presented.The substitution patterns of these thiazolines is particularly relevant for the synthesis of the tantazole, mirabazole, and thiangazole classes of natural products, which contain a linear array of these heterocycles.Methods for the formation of these thiazolines from 2-methyl cysteines and 2-halomethylalanines are discussed.
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Heathcock et al. (2002) studied this question.
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