Key result
Habitual exercise for 16 weeks prevented the augmented left ventricular end-diastolic chamber stiffness (P<0.01) and myocardial wall stiffness (P<0.001) produced by diabetes mellitus in male rats.
Why the study?
Does regular voluntary exercise attenuate myocardial stiffness in male rats with streptozocin-induced diabetes mellitus?
Does regular voluntary exercise attenuate myocardial stiffness in male rats with streptozocin-induced diabetes mellitus?
p-value: p=<0.01 for LVED chamber stiffness; <0.001 for myocardial wall stiffness
Regular voluntary exercise attenuates myocardial stiffness in diabetic rats without affecting the accumulation of advanced glycosylation end products.
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Supports exercise to mitigate diabetes-induced myocardial stiffening in rats; leaves open translation to human diabetic cardiomyopathy.
Woodiwiss et al. (1996) studied Streptozocin-induced diabetes mellitus. Regular voluntary (habitual) exercise vs. Diabetes mellitus without exercise was evaluated on Left ventricular end diastolic (LVED) chamber stiffness and myocardial wall stiffness (p=<0.01 for LVED chamber stiffness; <0.001 for myocardial wall stiffness). Habitual exercise for 16 weeks prevented the augmented left ventricular end-diastolic chamber stiffness (P<0.01) and myocardial wall stiffness (P<0.001) produced by diabetes mellitus in male rats.
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