Key result
Principal components analysis with varimax rotation of ultrasound recordings was feasible for following vascular pathology evolution and distinguishing between progressive and static situations.
Principal components analysis of ultrasound velocity fields is a feasible method to track vascular pathology evolution in animal models.
Supports PCA-ultrasound analysis in animal vascular models; hypothesis-generating and requires human validation before clinical consideration.
Vessel wall remodeling is involved in atherogenesis and in several important vascular diseases affecting mainly aged and prosthetic implanted patients. This adaptive response to pathological states in arterial hemodynamics strongly suggests that flow-derived stresses act as mechanical stimuli to the release of endothelium-derived vasoactive factors, leading to vascular alterations. As the correlation of intimal hyperplasia (IH) with blood flow alterations in arteries has been shown to be significant, and as it is well-known that clinical procedures carry a substantial risk of development of vascular disease, the relevance of local hemodynamics must be investigated to describe changes in compliance matching in prosthetic applications. The aim of our research is to investigate the use of principal components analysis, together with varimax rotation, in the individuation process of morphological characteristics of real time ultrasound in in vivo recordings of blood flow velocities, as provided by two different carotid perivascular manipulations. This would be of use in the clinical assessment of atherogenesis, hypertension, prosthetic replacement or more in general in all applications in which vascular tone may be impaired. Data recordings refer to previous animal experiments where the Moncada model was investigated by means of an ultrasound profilometer. The present study confirms the feasibility of the proposed analysis to follow vascular pathology evolution, distiguishing between an in progress and a static situation.
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Grigioni et al. (2004) studied Vascular pathology. Principal components analysis with varimax rotation was evaluated on Feasibility to follow vascular pathology evolution. Principal components analysis with varimax rotation of ultrasound recordings was feasible for following vascular pathology evolution and distinguishing between progressive and static situations.
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