Key result
A mathematical description of blood flow during reactive hyperemia identified vasomotor alterations induced by 1200 mg of ibuprofen (P < 0.05), even when traditional flow values did not.
Why the study?
Does a mathematical description of blood flow temporal profile identify vasomotor alterations induced by ibuprofen in healthy volunteers?
Does a mathematical description of blood flow temporal profile identify vasomotor alterations induced by ibuprofen in healthy volunteers?
p-value: p=< 0.05
A novel mathematical description of blood flow temporal profile during reactive hyperemia can detect vasomotor alterations not identified by traditional peak and basal flow values.
Mathematical modeling of reactive hyperemia may detect subtle ibuprofen-induced vasomotor changes missed by standard metrics; leaves open clinical translation.
Enhancing the knowledge about the characteristic of the vasomotor control can help physicians to improve the treatment of cardiovascular diseases and their consequences in people's daily activities. Vessels are generally evaluated from a static point of view, where some vascular features are obtained in a given space of time, or expressed as an average of some evaluation. The present study presents a method to assess some characteristics of the vasomotor control dynamics. Such a method is based on a mathematical description of the temporal profile of the blood flow observed during a reactive hyperemia condition induced by a protocol of 5 min of ischemia. The parameters for such a mathematical descriptive function were evaluated by searching for sensitivity to identify normal and vasomotor alterations induced by oral administration of ibuprofen (1200 mg) in ten healthy volunteers. The results indicated by the proposed mathematical description fitted appropriately experimental blood flow data (fitting-error of 0.18 ml/100 ml of tissue/min). Additionally, one parameter of the mentioned function was statistically different (P < 0.05) when one considers the normal and altered conditions of the vessel, even when the traditional peak and the basal flow values did not hint at the distinction.
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Macedo et al. (2008) studied Healthy volunteers (n=10). Ibuprofen vs. Normal condition (baseline) was evaluated on Parameter of the mathematical descriptive function for blood flow temporal profile (p=< 0.05). A mathematical description of blood flow during reactive hyperemia identified vasomotor alterations induced by 1200 mg of ibuprofen (P < 0.05), even when traditional flow values did not.
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