Key result
Two-dimensional and M-mode echocardiography successfully established normal reference ranges for cardiac dimensions and function in healthy Ghezel sheep.
Cross-Sectional (n=15)
No
This study establishes normal two-dimensional and M-mode echocardiographic reference ranges for Ghezel sheep, facilitating their use as an animal model in cardiovascular research.
Supports Ghezel sheep as a cardiovascular research model; leaves open validation in other species or clinical settings.
intercostal spaces using a 2.50 - 5.00 MHz phased array transducer. The following parameters were measured in two-dimensional echocardiography: left atrial diameter (LAD), mitral valve annulus (MVA), aortic sinus (AoS), aortic valve (AoV), pulmonary sinus (PuS), and pulmonary valve (PuV); and in M-mode echocardiography: interventricular septum (IVS), left ventricular internal diameter (LVID), left ventricular free wall (LVFW), right ventricle free wall (RVFW), right ventricle internal diameter (RVID). Calculated variables included the ratios LAD/Ao and Pu/AoS, and the fractional shortening (FS), end diastolic volume (EDV), end systolic volume (ESV), ejection fraction (EF), stroke volume (SV) and cardiac output (CO) of the left ventricle. In conclusion, echocardiographic parameters could be reliably assessed in Ghezel sheep and our study provided some normal echocardiographic reference ranges that might be useful in proper identification, visualization, and measurements of cardiac structures. Such findings could be useful to assess and to diagnose the specific heart diseases in sheep practice and also for experimental studies in sheep as an animal model used for research purposes in cardiovascular studies of human.
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Roustaei et al. (2021) conducted a cross-sectional in Healthy (n=15). Two-dimensional and M-mode echocardiography was evaluated on Normal echocardiographic reference ranges. Two-dimensional and M-mode echocardiography successfully established normal reference ranges for cardiac dimensions and function in healthy Ghezel sheep.
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