Key result
Histologic evaluation of a periauricular lesion in a middle-aged female suggests Kimura's disease is highly similar to subcutaneous angiolymphoid hyperplasia with eosinophilia.
Case Report (n=1)
Kimura's disease shares significant histologic similarities with subcutaneous angiolymphoid hyperplasia with eosinophilia, suggesting they belong to the same disease group.
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Should not alter diagnosis of periauricular lesions; leaves open whether Kimura's disease and ALHE represent a spectrum.
Subcutaneous masses removed from periauricular lesions showed histologic features of Kimura's disease. These consist of remarkable vascular proliferation and lymphoid follicles in the subcutis rather than lower dermis, with numerous infiltrations of tissue eosinophils. Moderate eosinophilia and high IgE levels in the peripheral blood, and positive intradermal test and RAST with candida antigen were observed, which are also characteristic of Kimura's disease. However, the patient is a middle‐aged female without any swollen lymph nodes or systemic involvement. Moreover, a few vessels with prompt endothelial cells were recognized histologically. This resembles subcutaneous angiolymphoid hyperplasia with eosinophilia and its allied diseases. Review of the relevant literature and study of our own case suggested that Kimura's disease is highly similar to subcutaneous angiolymphoid hyperplasia with eosinophilia and its related diseases. We surmise that Kimura's disease belongs to this group.
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Sawada et al. (1984) conducted a case report in Kimura's disease (n=1). Histologic evaluation of a periauricular lesion in a middle-aged female suggests Kimura's disease is highly similar to subcutaneous angiolymphoid hyperplasia with eosinophilia.
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