Kimura's Disease: Immunohistochemistry of Infiltrating Cells Using Monoclonal and Polyclonal Antibodies

This study reports immunohistochemical findings with polyclonal and monoclonal antibodies in a case of Kimura's disease, angiolymphoid hyperplasia with eosinophilia, which showed a histopathology similar to that of follicular lymphoma in the initial biopsy. Major findings in our case were the variations in distribution of eosinophils, mast cells and IgE producing plasma cells between the biopsies. No proliferation of eosinophils was noted in the initial biopsy. The follicular structures in Kimura's disease appeared immunohistochemically to have derived from a reactive inflammatory process. It is suggested that the frequency of eosinophils in Kimura's disease varies with the course of the disease and that there is no direct relationship between the distributions of mast cells and eosinophils.