Key result
The Baylor-Nikkiso centrifugal pump with a purging system successfully reduced thrombus formation and was suitable for at least 2 weeks of continuous operation as a circulatory support system in calves.
Why the study?
Does the Baylor-Nikkiso centrifugal pump with a purging system reduce thrombus formation in calves undergoing biventricular bypass?
Does the Baylor-Nikkiso centrifugal pump with a purging system reduce thrombus formation in calves undergoing biventricular bypass?
The addition of a purging system to the Baylor-Nikkiso centrifugal pump reduces thrombus formation, allowing for at least 2 weeks of continuous circulatory support in a preclinical model.
Answers are grounded in this paper and cite their sources.
Cautions against clinical adoption without human data; leaves open translation of purging systems for centrifugal pumps.
The Baylor-Nikkiso centrifugal pump is a magnetically coupled system with a V-ring seal separating the pump and the actuator chamber. To prevent thrombus formation behind the impeller and to extend the life of the pump to 2 weeks of continuous operation, we incorporated a purging chamber behind the V-ring seal. An external pump connected to this purging chamber infused fluid at a constant rate to wash the shaft-seal area. To evaluate the effectiveness of the purging system, we have carried out biventricular bypass experiments using calves. The purging system was successful in reducing the level of thrombus formation after 2 weeks of operation. The results of these studies confirmed that the Baylor-Nikkiso centrifugal pump with this purging system is suitable for at least 2 weeks of continuous operation as a circulatory support system.
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Naito et al. (1993) studied Circulatory support. Baylor-Nikkiso centrifugal pump with a purging system was evaluated on Thrombus formation level and suitability for continuous operation. The Baylor-Nikkiso centrifugal pump with a purging system successfully reduced thrombus formation and was suitable for at least 2 weeks of continuous operation as a circulatory support system in calves.
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