What is the clinical evidence from this study?

Study design: Other. Population: Hypertension (n=24). Intervention: Angiotensin II vs. Normotensive subjects. Primary outcome: Change in critical opening pressure (COP) of digital vessels.

What question did this study set out to answer?

To compare digital critical opening pressure and vascular resistance responses to intravenous angiotensin II in normotensive subjects and patients with essential or renal hypertension.

February 1, 1967Circulation ResearchOpen Access

Digital Vascular Response to Angiotensin II in Normotensive and Hypertensive Subjects

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Key result

Intravenous angiotensin II reduced critical opening pressure in 7 of 9 normotensive subjects, increased it in 7 of 8 essential hypertensives, and had little effect in 6 of 7 renal hypertensives.

Why the study?

Does intravenous angiotensin alter digital vessel critical opening pressure differently in normotensive versus hypertensive subjects?

Population

24 subjects

Comparison

Intravenous angiotensin at 4 mµg/kilo per min… vs Comparison between normotensive subjects…

Design

Cross-sectional

Authors

PGPeter GaskellUniversity of Birmingham

Discussion

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Implication

Differential angiotensin effects by hypertension etiology may exist; hypothesis-generating and should not yet change practice.

Key Points

To compare digital critical opening pressure and vascular resistance responses to intravenous angiotensin II in normotensive subjects and patients with essential or renal hypertension.
Assessed 9 normotensive subjects, 8 patients with essential hypertension, and 7 patients with renal hypertension.
Measured digital critical opening pressure (COP) after digital nerve block and during intravenous infusion of angiotensin II at 2 to 16 mµg/kg per min.
Estimated total digital vascular resistance via venous occlusion plethysmography.
Post-nerve-block COP was under 20 mm Hg in all 9 normotensives and 6 of 7 renal hypertensives, but exceeded 20 mm Hg in 7 of 8 essential hypertensives.
Intravenous angiotensin II at 4 mµg/kg per min reduced COP in 7 of 9 normotensive subjects, increased COP substantially in 7 of 8 essential hypertensives, and had minimal effect in 6 of 7 renal hypertensives.
Angiotensin II induced a significantly greater rise in systemic blood pressure in essential hypertensives than in normotensives, while increasing digital vascular resistance despite relaxing digital vessel smooth muscle in normal subjects.

Structured PICO

Does intravenous angiotensin alter digital vessel critical opening pressure differently in normotensive versus hypertensive subjects?

Population

24 subjects comprising 9 normotensives, 8 patients with essential hypertension, and 7 patients with renal hypertension.

Intervention

Intravenous angiotensin at 4 mµg/kilo per min after digital nerve block (with doses from 2 to 16 mµg/kilo per min tested in normotensives)

Comparator

Comparison between normotensive subjects, essential hypertensive patients, and renal hypertensive patients

Outcome

Change in critical opening pressure (COP) of digital vesselssurrogate

Angiotensin elicits qualitatively different vascular smooth muscle responses in essential hypertension compared to normotensive or renal hypertensive subjects.

Cite This Study

Peter Gaskell (1967) studied Hypertension (n=24). Angiotensin II vs. Normotensive subjects was evaluated on Change in critical opening pressure (COP) of digital vessels. Intravenous angiotensin II reduced critical opening pressure in 7 of 9 normotensive subjects, increased it in 7 of 8 essential hypertensives, and had little effect in 6 of 7 renal hypertensives.

synapsesocial.com/papers/6a9efdf4162e266843c36f80 https://doi.org/10.1161/01.res.20.2.174

Topics

Hypertension management

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Digital Vascular Response to Angiotensin II in Normotensive and Hypertensive Subjects

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Digital Vascular Response to Angiotensin II in Normotensive and Hypertensive Subjects

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider