Key result
Isolated rat hearts exhibited marked circadian rhythmicities in myocardial oxidative and nonoxidative metabolism and responsiveness to changes in workload and fatty acid availability.
Myocardial metabolism and contractile responsiveness to workload and fatty acid availability exhibit significant circadian rhythms in a rat model.
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May guide chronotherapy research; leaves open translation to human myocardium and clinical practice.
Durgan et al. (2007) studied Circadian rhythms in myocardial metabolism and contractile function. Circadian phase and oleate concentration vs. Different circadian phases (9 AM, 3 PM, 9 PM, 3 AM) was evaluated on Myocardial metabolism and contractile function response to workload challenge. Isolated rat hearts exhibited marked circadian rhythmicities in myocardial oxidative and nonoxidative metabolism and responsiveness to changes in workload and fatty acid availability.
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