March 11, 2008EP Europace
Resynchronization of the left ventricular contraction by tailored programming of right and left ventricular pacing
Key result
Optimized sequential biventricular pacing reduced intra-left ventricular electromechanical delay to 26 +/- 15 ms compared to 44 +/- 26 ms with simultaneous pacing (P=0.001).
Why the study?
Does tailored programming of right and left ventricular pacing improve intraventricular resynchronization compared to simultaneous biventricular pacing in patients with biventricular pacemakers?
Population
69 consecutive patients who underwent biventricular (BIV) pacemaker implantation
Comparison
Sequential biventricular pacing with an… vs Simultaneous biventricular pacing and baseline
Design
Cohort
Authors
Discussion
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Implication
Supports sequential VV optimization in CRT patients; hypothesis-generating for clinical outcomes in randomized trials.
Structured PICO
Does tailored programming of right and left ventricular pacing improve intraventricular resynchronization compared to simultaneous biventricular pacing in patients with biventricular pacemakers?
P
Population
69 consecutive patients who underwent biventricular pacemaker implantation.
I
Intervention
Sequential biventricular pacing with an individually optimized VV interval value between +80 ms and -80 ms
C
Comparator
Simultaneous biventricular pacing (BIV 0) and baseline
O
Outcome
Magnitude of intraventricular resynchronization (intra-LV electromechanical delay) measured using pulsed-wave tissue Doppler imagingsurrogate
Main Result
Absolute Event Rate: 26% vs 44%
p-value: p=0.001
Tailored programming of VV intervals in biventricular pacing significantly improves left ventricular resynchronization compared to simultaneous pacing.
Cite This Study
Brignole et al. (2008) studied Patients undergoing biventricular pacemaker implantation (n=69). Optimized sequential biventricular pacing vs. Simultaneous biventricular pacing (BIV 0) was evaluated on Intra-LV electromechanical delay (p=0.001). Optimized sequential biventricular pacing reduced intra-left ventricular electromechanical delay to 26 +/- 15 ms compared to 44 +/- 26 ms with simultaneous pacing (P=0.001).