Key result
Echo-guided CRT optimization significantly improves acute hemodynamics over baseline configurations.
Why the study?
Different pacing modalities in CRT produce variable activation patterns and haemodynamic changes, necessitating evaluation of acute haemodynamic effects with different CRT configurations.
Does Doppler echocardiography-guided optimization of CRT configurations improve acute haemodynamic parameters in heart failure patients with IVCD?
Population
26 heart failure patients with IVCD and CRT device implanted
Comparison
Different CRT pacing configurations and atrioventricular delays
Design
Observational study with intraindividual comparison
Follow-up
Acute
Authors
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Variable acute haemodynamic responses seen across CRT configurations; leaves open optimal selection for long-term outcomes.
Does Doppler echocardiography-guided optimization of CRT configurations improve acute haemodynamic parameters in heart failure patients with IVCD?
p-value: p=<0.001
Doppler echocardiography-guided optimization of CRT configurations produces marked acute improvement in cardiac cycle timing, highlighting the importance of individualized settings.
Stockburger et al. (2006) studied Heart failure with intraventricular conduction delay (n=26). Optimized cardiac resynchronization therapy vs. Baseline/non-optimized settings was evaluated on Acute haemodynamic changes (LVPEI, IVD, MPI, FTc) (p=<0.001). Optimized cardiac resynchronization therapy significantly improved acute haemodynamic parameters, including left ventricular pre-ejection interval and myocardial performance index (P<0.001 for all).
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