Key result
Exercise training significantly increased peak oxygen uptake (WMD 6.11; 95% CI 4.73 to 7.50) and improved left ventricular ejection fraction and 6-minute walk test distance in patients with ANOCA.
Why the study?
ANOCA is highly prevalent, but evidence regarding exercise training for its treatment remains inadequate.
Does exercise training improve cardiopulmonary function, exercise capacity, and endothelial function in patients with angina with nonobstructive coronary arteries?
Meta-Analysis
Does exercise training improve cardiopulmonary function, exercise capacity, and endothelial function in patients with angina with nonobstructive coronary arteries?
Mean Difference: 6.11 (95% CI 4.73–7.5)
Exercise training improves cardiopulmonary function, exercise capacity, and endothelial function in patients with angina with nonobstructive coronary arteries.
Supports exercise training in ANOCA; confirms benefits on peak VO2, LVEF, and 6MWT across pooled trials.
Angina with nonobstructive coronary arteries (ANOCA) is a highly prevalent heart disease. The evidence on exercise training (ET) for the treatment of ANOCA, however, is still inadequate. This meta-analysis aims to provide a comprehensive assessment of the effect of ET in patients with ANOCA. Studies were searched from PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, VIP, and WanFang from inception to 15 January 2024. The quality of included studies was assessed using the Cochrane risk of bias tool. Heterogeneity among the studies was evaluated using Cochran's Q test and I2 statistic, and subgroup analysis based on gender was performed to explore potential sources of heterogeneity. A total of 12 studies were included in this meta-analysis. The pooled results showed that ET significantly increased the peak oxygen uptake (peak VO 2 ) [weighted mean difference (WMD) = 6.11, 95% confidence interval (CI): 4.73 to 7.50], left ventricular ejection fraction (WMD = 7.66, 95% CI: 5.53 to 9.78), and 6 min walking test (WMD = 55.55; 95% CI: 16.23 to 94.87). Nitric oxide (WMD = 20.18, 95% CI: 19.16 to 21.21) and peripheral arterial tonometry (WMD = 0.16, 95% CI: 0.11 to 0.21) were higher, and matrix metalloproteinase-9 (WMD = -8.02, 95% CI: -9.21 to -6.84) was lower in ET group. In conclusion, our findings indicated that ET could improve cardiopulmonary function, exercise capacity, and endothelial function, which could be recommended for the treatment of ANOCA patients.
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Yuan et al. (2024) conducted a meta-analysis in Angina with nonobstructive coronary arteries (ANOCA). Exercise training vs. Control was evaluated on Peak oxygen uptake (peak VO2) (WMD 6.11, 95% CI 4.73 to 7.50). Exercise training significantly increased peak oxygen uptake (WMD 6.11; 95% CI 4.73 to 7.50) and improved left ventricular ejection fraction and 6-minute walk test distance in patients with ANOCA.
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