Key result
CT-pro-ET-1 peak levels on day 1 after ischemic stroke were not independently associated with unfavorable functional outcome (OR 1.05) but independently predicted 90-day mortality (HR 1.50).
Why the study?
Endothelins play a role in the pathophysiology of ischemic stroke, prompting evaluation of the incremental prognostic value of C-terminal-pro-endothelin-1.
Does CT-pro-ET-1 level on day 1 predict functional outcome and mortality in acute ischemic stroke patients?
Population
361 consecutively enrolled ischemic stroke patients
Comparison
Prognostic models with vs without CT-pro-ET-1
Design
Cohort study
Follow-up
90 days
Authors
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CT-pro-ET-1 may add prognostic value post-ischemic stroke; hypothesis-generating and needs prospective validation before clinical use.
Cohort (n=361)
Blinded outcome assessment
No
Does CT-pro-ET-1 level on day 1 predict functional outcome and mortality in acute ischemic stroke patients?
Odds Ratio: 1.05 (95% CI 0.88–1.25)
p-value: p=0.59
CT-pro-ET-1 measured on day 1 after admission adds incremental prognostic value for predicting 90-day mortality in patients with acute ischemic stroke.
Westphal et al. (2021) conducted a cohort in Acute ischemic stroke (n=361). C-terminal-pro-endothelin-1 (CT-pro-ET-1) vs. Lower levels of CT-pro-ET-1 was evaluated on Unfavorable functional outcome after 90 days (mRS 3-6) (OR 1.05, 95% CI 0.88-1.25, p=0.59). CT-pro-ET-1 peak levels on day 1 after ischemic stroke were not independently associated with unfavorable functional outcome (OR 1.05) but independently predicted 90-day mortality (HR 1.50).
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