Key result
Rat SK1 channels are selectively colocalized with D class L-type calcium channels in the soma of hippocampal CA1 neurons, supporting the somatic origin of the slow afterhyperpolarization.
Population
Rat CA1 hippocampal pyramidal neurons (in hippocampal slices)
Design
Preclinical
Authors
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Advances rodent CA1 electrophysiology models; leaves open translation to humans or disease states.
The slow afterhyperpolarization in hippocampal CA1 neurons is somatic in origin, resulting from delayed facilitation of D class L-type Ca2+ channels colocalized with rSK1 channels.
Bowden et al. (2001) studied None (Healthy animal model). Immunocytochemistry and electrophysiology was evaluated on Subcellular localization and functional coupling of rSK1 and L-type calcium channels. Rat SK1 channels are selectively colocalized with D class L-type calcium channels in the soma of hippocampal CA1 neurons, supporting the somatic origin of the slow afterhyperpolarization.
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