Why the study?
Does profound oligemic hypotension alter cerebral function and intracranial pressure in a dog model?
Population
12 healthy mongrel dogs weighing between 15 and 20 kg
Comparison
Profound oligemic hypotension induced by rapid… vs Baseline control period prior to hemorrhage
Design
Preclinical
Follow-up
up to 2.5 hours of observation post-reinfusion
Authors
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Cerebral autoregulation may preserve function despite profound oligemia in dogs; leaves open translation to human ICP or resuscitation strategies.
Does profound oligemic hypotension alter cerebral function and intracranial pressure in a dog model?
Cerebral function is preserved during profound systemic hypotension in a dog model, despite significant reductions in arterial pressure and carotid blood flow.
Yashon et al. (1971) studied this question.
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