Why the study?
Does prolonged arterial hypotension cause functional cardiac deterioration in a canine model?
Population
Dogs undergoing extensive surgical procedures
Comparison
Episodes of arterial hypotension vs Operated control dogs without hypotensive episodes
Design
Preclinical
Follow-up
Up to 150 minutes after the end of hypotension
Authors
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Suggests caution with prolonged hypotension in models; leaves open translation to human shock or perioperative care.
Does prolonged arterial hypotension cause functional cardiac deterioration in a canine model?
Prolonged arterial hypotension leads to progressive functional cardiac deterioration and peripheral vascular bed dysfunction in a canine model.
GOMEZ et al. (1964) studied this question.
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