Why the study?
Is the irreversible stage of hemorrhagic shock caused by progressive cardiac failure in a dog model?
Population
Normal dogs and dogs in various stages of hemorrhagic shock
Comparison
Induction of hemorrhagic shock and manipulation… vs Normal state and early stages of shock
Design
Preclinical
Authors
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Should not alter clinical shock management; leaves open cardiac failure as driver of irreversibility beyond this canine model.
Is the irreversible stage of hemorrhagic shock caused by progressive cardiac failure in a dog model?
This preclinical study provides evidence that the irreversible stage of hemorrhagic shock is driven by rapid progressive cardiac failure.
Crowell et al. (1962) studied this question.
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