Key result
Hospital admissions for cardiac Chagas disease in the United States significantly increased from 2003 to 2011 (OR 1.054), with 63% of patients experiencing major adverse events during hospitalization.
Why the study?
Chagas disease has been increasingly encountered as a cause of cardiovascular disease in the United States, prompting an examination of trends in hospital admissions and cardiovascular outcomes.
Observational (n=949)
Yes
Odds Ratio: 1.054 (95% CI 1.028–1.081)
p-value: p=<0.0001
Hospital admissions for cardiac Chagas disease in the US increased significantly from 2003 to 2011, with a high prevalence of serious cardiovascular abnormalities and in-hospital adverse events.
Rising US cardiac Chagas admissions signal need for clinician awareness; leaves open optimal screening and management strategies.
BACKGROUND: , has been increasingly encountered as a cause of cardiovascular disease in the United States. We aimed to examine trends of hospital admissions and cardiovascular outcomes of cardiac CD (CCD). METHODS: Search of 2003-2011 Nationwide Inpatient Sample database identified 949 (age 57±16 years, 51% male, 72.5% Hispanic) admissions for CCD. RESULTS: A significant increase in the number of admissions for CCD was noted during the study period (OR=1.054; 95% CI=1.028-1.081; P< 0.0001); 72% were admitted to Southern and Western hospitals. Comorbidities included hypertension (40%), coronary artery disease (28%), hyperlipidemia (26%), tobacco use (12%), diabetes (9%), heart failure (5%) and obesity (2.2%). Cardiac abnormalities noted during hospitalization included atrial fibrillation (27%), ventricular tachycardia (23%), sinoatrial node dysfunction (5%), complete heart block (4%), valvular heart disease (6%)] and left ventricular aneurysms (5%). In-hospital mortality was 3.2%. Other major adverse events included cardiogenic shock in 54 (5.7%), cardiac arrest in 30 (3.2%), acute heart failure in 88 (9.3%), use of mechanical circulatory support in 29 (3.1%), and acute stroke in 34 (3.5%). Overall, 63% suffered at least one adverse event. Temporary (2%) and permanent (3.5%) pacemakers, implantable cardioverter defibrillators (10%), and cardiac transplant (2.1%) were needed for in-hospital management. CONCLUSIONS: Despite the remaining concerns about lack of awareness of CCD in the US, an increasing number of hospital admissions were reported from 2003-2011. Serious cardiovascular abnormalities were highly prevalent in these patients and were frequently associated with fatal and nonfatal complications.
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Shirani et al. (2020) conducted an observational in Cardiac Chagas disease (n=949). Calendar year (annual trend) was evaluated on Annual rate of hospital admission for cardiac Chagas disease (OR 1.054, 95% CI 1.028-1.081, p=<0.0001). Hospital admissions for cardiac Chagas disease in the United States significantly increased from 2003 to 2011 (OR 1.054), with 63% of patients experiencing major adverse events during hospitalization.
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