Key result
Pretreatment with lithium carbonate increased baseline sodium excretion but attenuated natriuresis during alpha-human atrial natriuretic peptide infusion in healthy men.
Why the study?
Does lithium carbonate pretreatment alter the renal actions of alpha-human atrial natriuretic peptide in healthy men?
RCT (n=8)
Does lithium carbonate pretreatment alter the renal actions of alpha-human atrial natriuretic peptide in healthy men?
Lithium pretreatment attenuates the natriuretic effect of alpha-human atrial natriuretic peptide, suggesting lithium clearance may not be a pure marker of proximal renal tubular sodium handling.
Challenges lithium clearance as pure proximal marker; leaves open its validity in renal research.
alpha-Human atrial natriuretic peptide (7.5 pmol min-1 kg-1) was infused intravenously into eight healthy men after pretreatment with lithium carbonate (750 mg) or placebo. 2. Baseline sodium excretion was significantly increased after lithium, but the natriuresis during infusion of alpha-human atrial natriuretic peptide was attenuated. 3. Similar decreases in plasma renin activity with infusion of alpha-human atrial natriuretic peptide occurred on both days. 4. Administration of lithium may be associated with pharmacological effects and further work is required to validate the use of lithium clearance as a marker of proximal renal tubular sodium handling.
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Freestone et al. (1990) conducted an RCT in Healthy (n=8). Lithium carbonate vs. Placebo was evaluated on Natriuresis during infusion of alpha-human atrial natriuretic peptide. Pretreatment with lithium carbonate increased baseline sodium excretion but attenuated natriuresis during alpha-human atrial natriuretic peptide infusion in healthy men.
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