Key result
Carotid intima-media thickness remains constant in healthy children younger than 10 years regardless of sex or BMI, but significantly increases in subjects aged 11 to 15 years.
Cross-Sectional (n=280)
Absolute Event Rate: 0.43% vs 0.42%
p-value: p=0.243
In healthy children, carotid intima-media thickness remains constant under age 10 regardless of sex or BMI, but increases after age 10.
Normative CIMT data in healthy children should not guide practice; leaves open prognostic value for future events.
BACKGROUND: Carotid intima-media thickness (CIMT) has been shown to be increased in children and adolescents with traditional cardiovascular risk factors such as obesity, hypertension, and chronic kidney disease, compared with those of healthy children. OBJECTIVE: To assess the influence of sex, age and body mass index (BMI) on the CIMT in healthy children and adolescents aged 1 to 15 years. METHODS: A total of 280 healthy children and adolescents (males, n=175; mean age, 7.49±3.57 years; mean BMI, 17.94±4.1 kg/m2) were screened for CIMT assessment. They were divided into 3 groups according to age: GI, 1 to 5 years [n=93 (33.2%); males, 57; mean BMI, 16±3 kg/m2]; GII, 6 to 10 years [n=127 (45.4%); males, 78; mean BMI, 17.9±3.7 kg/m2], and GIII, 11 to 15 years [n=60 (21.4%); males, 40; mean BMI, 20.9±4.5 kg/m2]. RESULTS: There was no significant difference in CIMT values between male and female children and adolescents (0.43±0.06 mm vs. 0.42±0.05 mm, respectively; p=0.243). CIMT correlated with BMI neither in the total population nor in the 3 age groups according to Pearson correlation coefficient. Subjects aged 11 to 15 years had the highest CIMT values (GI vs. GII, p=0.615; GI vs. GIII, p=0.02; GII vs. GIII, p=0.004). CONCLUSIONS: CIMT is constant in healthy children younger than 10 years, regardless of sex or BMI. CIMT increases after the age of 10 years.
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Baroncini et al. (2016) conducted a cross-sectional in Healthy children and adolescents (n=280). Age, sex, and BMI vs. Reference groups (females, younger age groups) was evaluated on Carotid intima-media thickness (CIMT) difference between males and females (p=0.243). Carotid intima-media thickness remains constant in healthy children younger than 10 years regardless of sex or BMI, but significantly increases in subjects aged 11 to 15 years.
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