Key result
Leukopenia did not prevent pulmonary hypertension after heparin-protamine administration in pigs, with mean pulmonary arterial pressure increasing by 46% in leukopenic pigs and 74% in controls.
Why the study?
Does leukopenia prevent pulmonary hypertension after heparin-protamine administration in pigs?
Does leukopenia prevent pulmonary hypertension after heparin-protamine administration in pigs?
Absolute Event Rate: 46% vs 74%
Leukocytes do not appear to contribute to the severe pulmonary hypertension observed after heparin-protamine administration in a pig model.
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Leukopenia fails to block heparin-protamine pulmonary hypertension in pigs; leaves open non-leukocyte mechanisms for further study.
Habazettl et al. (1992) studied Pulmonary hypertension after heparin-protamine (n=17). Leukopenia (induced by cyclophosphamide) vs. Control group was evaluated on Increase in mean pulmonary arterial pressure. Leukopenia did not prevent pulmonary hypertension after heparin-protamine administration in pigs, with mean pulmonary arterial pressure increasing by 46% in leukopenic pigs and 74% in controls.
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