Key result
An acute exercise session performed 16 hours or 4 hours before a meal significantly reduced triglyceride AUC by 26% and 15%, respectively, compared with no exercise (P<0.05).
Why the study?
Does an acute exercise session performed 16 or 4 hours before a high-fat meal reduce postprandial lipemia and improve endothelial function in healthy men?
RCT (n=12)
Does an acute exercise session performed 16 or 4 hours before a high-fat meal reduce postprandial lipemia and improve endothelial function in healthy men?
Effect estimate: -26% (EX-16) and -15% (EX-4)
p-value: p=< 0.05
An acute exercise session performed either 4 or 16 hours prior to a high-fat meal significantly reduces postprandial lipemia in healthy men, though it does not significantly alter endothelial function.
Acute pre-meal exercise attenuates postprandial lipemia without improving endothelial function in healthy men; leaves open effects in patients or on outcomes.
PURPOSE: The purpose of this study was to examine the effects of previous exercise on metabolic, hormonal, and endothelial responses to an oral fat-tolerance test (OFTT). METHODS: Twelve healthy, recreationally trained men (age = 22.3 +/- 2.5 yr, weight = 80.7 +/- 12.4 kg, BMI = 25.1 +/- 3.1 kg.m(-2)) volunteered for this study. In a crossover fashion, subjects completed three OFTT trials that involved no exercise (NoEx) or exercise performed 16 h (EX-16) or 4 h (EX-4) before the ingestion of a meal (13 kcal.kg(-1) and 1.4 g of fat per kilogram of body weight). Blood was collected before and after the meal and hourly for 6 h. Brachial artery reactivity was measured using ultrasound before and at 2, 4, and 6 h after the meal. Dietary intake and exercise were standardized 4 d before the OFTT. The exercise session consisted of six resistance exercises and 30 min of running on a treadmill. The washout period between trials was, on average, 5 d. RESULTS: Compared with NoEx, there were significant (P < 0.05) decreases in triglyceride area under the curve (AUC) during EX-16 (-26%) and EX-4 (-15%). Compared with NoEx, there were decreases in insulin AUC during EX-16 (-7%, P < 0.05) and EX-4 (-5%, NS). EX-4 resulted in a significantly larger fasting arterial diameter than EX-16 and NoEx, but there were no other significant effects on endothelial function. Lipemic variables did not show correlations with endothelium function for any of the trials. CONCLUSION: An acute exercise session, regardless of the time point chosen (i.e., EX-16 or EX-4), reduced to a similar extent the total and incremental lipemic responses compared with the NoEx condition.
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Silvestre et al. (2008) conducted an RCT in healthy, recreationally trained men (n=12). Exercise 16 h (EX-16) or 4 h (EX-4) before a meal vs. No exercise (NoEx) was evaluated on Triglyceride area under the curve (AUC) (-26% (EX-16) and -15% (EX-4), p=< 0.05). An acute exercise session performed 16 hours or 4 hours before a meal significantly reduced triglyceride AUC by 26% and 15%, respectively, compared with no exercise (P<0.05).
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