The designed hybrids 5–11 containing the DNA cleavable enediyne 4 and naturally occurring DNA intercalators 12–18cleave DNA effectively under alkaline conditions without any additive; the hybrids 5 and 11 exhibit the strongest DNA-cleaving abilities with the identical high purine base (G>A) selectivities for their DNA-cleavage profiles.
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Toshima et al. (1993) studied this question.
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