Key result
Candesartan cilexetil (16-32 mg daily) reduced mean SBP/DBP by 18.7/13.1 mm Hg as monotherapy in essential hypertension, with consistent further reductions when used as add-on therapy.
Why the study?
Does candesartan cilexetil reduce blood pressure in patients with untreated or uncontrolled hypertension?
Population
6,465 patients with untreated or uncontrolled hypertension despite various antihypertensive medications…
Design
Cohort, open-label
Follow-up
8 weeks
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Supports candesartan in essential hypertension; extends observational data but leaves open need for randomized confirmation.
Does candesartan cilexetil reduce blood pressure in patients with untreated or uncontrolled hypertension?
Candesartan cilexetil is effective and well-tolerated for lowering blood pressure as monotherapy or add-on therapy in patients with uncontrolled hypertension.
A 2001 study studied Hypertension (n=6,465). Candesartan cilexetil was evaluated on Reduction in mean systolic and diastolic blood pressure. Candesartan cilexetil (16-32 mg daily) reduced mean SBP/DBP by 18.7/13.1 mm Hg as monotherapy in essential hypertension, with consistent further reductions when used as add-on therapy.
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