Key result
Modulation of salt intake increased active kallikrein excretion by 136% (p<0.002) but did not significantly change elevated blood pressure in hypertensive Fawn-hooded rats.
Why the study?
Does modulation of salt intake affect urinary kallikrein, plasma renin activity, and blood pressure in hypertensive Fawn-hooded rats?
Population
Hypertensive Fawn-hooded (FH) male rats and matched normotensive Wistar rats
Comparison
Low-salt diet or high-salt diet vs Standard rat chow (0.39% NaCl)
Design
Preclinical
Authors
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Salt modulation fails to alter established hypertension despite kallikrein changes in this model; leaves open its role in other hypertension contexts.
Does modulation of salt intake affect urinary kallikrein, plasma renin activity, and blood pressure in hypertensive Fawn-hooded rats?
Modulation of urinary kallikrein and plasma renin activities via salt intake does not affect established hypertension in the Fawn-hooded rat model.
Gilboa et al. (2008) studied Hypertension. Low-salt or high-salt diet vs. Standard rat chow (0.39% NaCl) was evaluated on Blood pressure. Modulation of salt intake increased active kallikrein excretion by 136% (p<0.002) but did not significantly change elevated blood pressure in hypertensive Fawn-hooded rats.
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