Key result
Salt loading increased systolic blood pressure only in Dahl-Iwai salt-sensitive rats, which demonstrated lower urinary kallikrein quantity and activity compared to salt-resistant and Sprague-Dawley rats.
Dahl-Iwai salt-sensitive rats have an impaired ability to produce active renal kallikrein, which may play a role in their salt-induced blood pressure elevation.
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Hypothesis-generating for renal kallikrein in salt-sensitive hypertension models; leaves open relevance to human disease.
Hiroyuki Yoshida (1997) studied Salt-sensitive hypertension. Salt loading vs. Control period / Sprague-Dawley rats was evaluated on Urinary kallikrein quantity and activity. Salt loading increased systolic blood pressure only in Dahl-Iwai salt-sensitive rats, which demonstrated lower urinary kallikrein quantity and activity compared to salt-resistant and Sprague-Dawley rats.
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