Key result
Captopril normalized blood pressure, stabilized proteinuria, and significantly lowered the incidence of glomerulosclerosis in spontaneously hypertensive Fawn Hooded rats.
Why the study?
Does captopril prevent renal damage in spontaneously hypertensive Fawn Hooded rats?
Population
Male spontaneously hypertensive Fawn Hooded rats at 5 months of age with mild hypertension, proteinuria, and…
Comparison
Captopril treatment from 5 months to 12 months… vs Untreated spontaneously hypertensive Fawn Hooded…
Design
Preclinical
Follow-up
7 months (from 5 to 12 months of age)
Authors
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Supports ACEI renoprotection after established injury in rat models; leaves open translation to human hypertensive CKD.
Does captopril prevent renal damage in spontaneously hypertensive Fawn Hooded rats?
Captopril protects against structural renal damage in hypertensive rats even when treatment is initiated after glomerular injury is established.
Westenend et al. (1992) studied Hypertension, proteinuria, and glomerulosclerosis. Captopril vs. Untreated rats was evaluated on Renal function and incidence of glomerulosclerosis. Captopril normalized blood pressure, stabilized proteinuria, and significantly lowered the incidence of glomerulosclerosis in spontaneously hypertensive Fawn Hooded rats.
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