Why the study?
Is the G-50T polymorphism of the CYP2J2 gene associated with an increased risk of coronary artery disease?
Population
289 patients with coronary artery disease and 255 control subjects. Initial sequencing was performed in a…
Comparison
Presence of the G-50T single nucleotide… vs Absence of the G-50T SNP (wild-type)
Design
Case-control
Key result
The G-50T polymorphism in the CYP2J2 gene is independently associated with an increased risk of coronary artery disease (OR 2.23; 95% CI 1.04-4.79).
Authors
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No clinical action warranted from this association; leaves open replication in prospective cohorts and risk stratification utility.
Case-Control (n=544)
Is the G-50T polymorphism of the CYP2J2 gene associated with an increased risk of coronary artery disease?
The G-50T polymorphism in the CYP2J2 promoter is independently associated with an increased risk of coronary artery disease, likely driven by decreased promoter activity and lower levels of protective EET metabolites.
Odds Ratio: 2.23 (95% CI 1.04–4.79)
Absolute Event Rate: 17.3% vs 10.6%
p-value: p=0.026
Spiecker et al. (2004) conducted a case-control in Coronary artery disease (n=544). G-50T polymorphism in the CYP2J2 gene vs. Individuals without the G-50T polymorphism was evaluated on Coronary artery disease (OR 2.23, 95% CI 1.04-4.79, p=0.026). The G-50T polymorphism in the CYP2J2 gene is independently associated with an increased risk of coronary artery disease (OR 2.23; 95% CI 1.04-4.79).