Key result
The CYP2J2 G-50T polymorphism was independently associated with an increased risk of coronary artery disease (p=0.04).
Why the study?
The study was conducted to analyze the impact of a genetic variant in CYP2J2 on CAD in the Telangana region of the Indian population.
Is the CYP2J2 G-50T polymorphism associated with an increased risk of coronary artery disease in a South Indian population?
Case-Control (n=210)
Is the CYP2J2 G-50T polymorphism associated with an increased risk of coronary artery disease in a South Indian population?
p-value: p=0.04
A functionally relevant polymorphism of the CYP2J2 gene (G-50T) is independently associated with an increased risk of coronary artery disease in a South Indian population.
Hypothesis-generating for CYP2J2 variants in South Indian CAD risk; does not support genotyping or practice change.
BACKGROUND: The cytochrome P-450 2J2 (CYP2J2) is known to be one of the major enzymes of epoxygenase pathway of arachidonic acid in extrahepatic tissues, which produces series of regioisomeric cis-epoxyeicosatrienoic acids (EETs) such as 5,6-, 8,9-, 11,12-, and 14,15-EETs. In the present study, we analyzed the impact of a genetic variant in CYP2J2 on coronary artery disease (CAD) in the Telangana region of Indian population. MATERIAL AND METHODS: The case-control study consisted of 100 CAD cases and 110 healthy controls. The deoxyribonucleic acid was extracted using the salting out method. Genotyping and gene expression was performed by polymerase chain reaction (PCR)-restriction fragment length polymorphism and real-time-PCR methods. RESULTS: In the present study, the percentage of smokers, alcoholics, hypertensive patients, and diabetics was high. Increase in fasting glucose, urea, creatinine, fasting triglycerides, total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), total cholesterol/high-density lipoprotein (TC/HDL), LDL/HDL, homocysteine, and C-reactive protein levels were significantly higher in patients with CAD than in controls (p < 0.001). CYP2J2 G-50T was associated with CAD (p = 0.04). The mRNA expression of CYP2J2 showed altered gene expression in this study among CAD patients in comparison with control (p = 0.01). CONCLUSIONS: A functionally relevant polymorphism of the CYP2J2 gene was independently associated with an increased risk of CAD.
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Tantray et al. (2018) conducted a case-control in Coronary artery disease (CAD) (n=210). CYP2J2 G-50T genetic variant vs. Healthy controls was evaluated on Association with coronary artery disease (p=0.04). The CYP2J2 G-50T polymorphism was independently associated with an increased risk of coronary artery disease (p=0.04).
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