Key result
The concomitant presence of CETP B1 and eNOS 4a alleles significantly increased the risk of CAD in the Malay group (OR 33.8, P<.001) and the Indian group (OR 10.9, P=.031).
Why the study?
Does the presence of CETP and eNOS gene polymorphisms increase the risk of CAD in a multi-ethnic Malaysian population?
Case-Control (n=338)
Does the presence of CETP and eNOS gene polymorphisms increase the risk of CAD in a multi-ethnic Malaysian population?
Odds Ratio: 33.8
p-value: p=<.001
The combination of CETP B1 and eNOS 4a alleles significantly increases the risk of coronary artery disease in Malay and Indian populations, highlighting a novel ethnic-specific gene-gene interaction.
Supports ethnic-specific CETP-eNOS interaction raising CAD risk in Malays and Indians; hypothesis-generating and requires prospective validation.
Genetic variants of cholesteryl ester transfer protein (CETP) and endothelial nitric oxide synthase (eNOS) influence high-density lipoprotein cholesterol (HDL-C) metabolism and nitric oxide (NO) synthesis, respectively, and might increase the risk of coronary artery disease (CAD). This study is to investigate the relationship between genetic polymorphisms and the risk of CAD and to evaluate their potential interactions. A total of 237 patients with CAD and 101 controls were genotyped. The association of the polymorphism with the risk of CAD varied among the ethnic groups. Moreover, the concomitant presence of both CETP B1 and eNOS 4a alleles significantly increased the risk of CAD in the Malay group (OR = 33.8, P < .001) and the Indian group (OR = 10.9, P = .031) but not in the Chinese group. This study has identified a novel ethnic-specific gene-gene interaction and suggested that the combination of CETP B1 allele and eNOS 4a allele significantly increases the risk of CAD in Malays and Indians.
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Chu et al. (2015) conducted a case-control in Coronary Artery Disease (n=338). Concomitant presence of CETP B1 and eNOS 4a alleles vs. Absence of this combination / Controls was evaluated on Risk of coronary artery disease (OR 33.8, p=<.001). The concomitant presence of CETP B1 and eNOS 4a alleles significantly increased the risk of CAD in the Malay group (OR 33.8, P<.001) and the Indian group (OR 10.9, P=.031).
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