Key result
The concomitant presence of both CETP B1 and NOS3 T alleles significantly increased the risk of coronary artery disease by 18.1-fold compared to controls.
Why the study?
Does the interaction between NOS3 T allele and CETP B1 allele increase the risk of CAD and T2DM?
Case-Control (n=400)
No
Does the interaction between NOS3 T allele and CETP B1 allele increase the risk of CAD and T2DM?
Odds Ratio: 18.1 (95% CI 4.2–76.8)
p-value: p=<0.001
The concomitant presence of NOS3 T and CETP B1 alleles strongly increases the risk of CAD and T2DM in a Western Iranian population.
May indicate genetic interaction elevating CAD risk in Iranians; hypothesis-generating and requires prospective validation before any clinical use.
BACKGROUND: The present study was conducted to investigate the possible outcome of interaction between endothelial nitric oxide (NOS3) G894T and cholesteryl ester transfer TaqIB variants on the risk of coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM). The sample included a total of 207 CAD patients (102 CAD patients with T2DM and 105 CAD patients without T2DM). There were also 101 patients with T2DM and 92 age- and sex-matched healthy individuals as controls. All study participants were from Western Iran. The sample was genotyped by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: The presence of NOS3 T allele was not associated with the risk of CAD or T2DM, and the CETP B1 allele was only significantly associated with the increased risk of CAD in total CAD patients (odds ratio (OR) = 5.1, p = 0.019). However, the concomitant presence of both CETP B1 and NOS3 T alleles significantly increased the risk of CAD in total CAD patients (OR = 18.1, p < 0.001), in CAD patients without T2DM (OR = 27.1, p = 0.03), and in CAD patients with T2DM (OR = 13.5, p = 0.002). Also, the presence of both alleles increased the risk of T2DM (OR = 12, p = 0.004). CONCLUSIONS: Our findings, for the first time, indicate that NOS3 T allele strongly interacts with CETP B1 allele to augment the risk of CAD and T2DM in the population of Western Iran.
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Rahimi et al. (2012) conducted a case-control in Coronary artery disease and type 2 diabetes mellitus (n=400). Concomitant presence of CETP B1 and NOS3 T alleles vs. Absence of both alleles was evaluated on Risk of coronary artery disease (OR 18.1, 95% CI 4.2-76.8, p=<0.001). The concomitant presence of both CETP B1 and NOS3 T alleles significantly increased the risk of coronary artery disease by 18.1-fold compared to controls.
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