Key result
Chronic combination therapy with glibenclamide and metformin improved functional recovery, including heart rate and left ventricular developed pressure, in isolated diabetic rat hearts post-ischaemia.
Why the study?
Does chronic treatment with glibenclamide and/or metformin affect the tolerance to ischaemia in isolated hearts from Zucker Diabetic Fatty rats?
Does chronic treatment with glibenclamide and/or metformin affect the tolerance to ischaemia in isolated hearts from Zucker Diabetic Fatty rats?
Chronic combination therapy with glibenclamide and metformin improves functional recovery following ischemia-reperfusion in isolated hearts of a type 2 diabetes rat model.
No takes yet. Share an insight, caveat, or question.
Should not change antidiabetic prescribing; hypothesis-generating for cardioprotection in diabetic ischaemia models.
Lavanchy et al. (2003) studied Type 2 diabetes (animal model). Glibenclamide and/or metformin vs. Untreated control was evaluated on Functional recovery (heart rate, left ventricular developed pressure, rate pressure product, coronary flow) after ischaemia and reperfusion. Chronic combination therapy with glibenclamide and metformin improved functional recovery, including heart rate and left ventricular developed pressure, in isolated diabetic rat hearts post-ischaemia.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: