Key result
Penicillin prophylaxis in women with premature rupture of membranes significantly reduced the incidence of chorioamnionitis compared to placebo (2% vs 14%, p<0.05).
Why the study?
Does penicillin prophylaxis reduce infectious morbidity in women with premature rupture of membranes and their infants?
Population
221 women with premature rupture of membranes and their children.
Comparison
Penicillin 5 million units intravenously twice… vs Placebo or no treatment.
Design
Cohort
Authors
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May support penicillin prophylaxis in PROM; leaves open confirmation of maternal-neonatal benefits in RCTs.
RCT (n=221)
Does penicillin prophylaxis reduce infectious morbidity in women with premature rupture of membranes and their infants?
Absolute Event Rate: 2% vs 14%
p-value: p=<0.05
Penicillin prophylaxis in women with premature rupture of membranes decreases maternal and neonatal infectious morbidity, and prolonged PROM does not impair long-term outcomes for the children.
Kurki et al. (1992) conducted an RCT in Premature rupture of membranes (PROM) (n=221). Penicillin vs. Placebo was evaluated on Chorioamnionitis (p=<0.05). Penicillin prophylaxis in women with premature rupture of membranes significantly reduced the incidence of chorioamnionitis compared to placebo (2% vs 14%, p<0.05).
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