Key result
Porcine resistance arteries produced significantly less nitric oxide in response to A23187 compared to epicardial conduit arteries (10.80 vs 17.00 nmol/microgram protein; P<0.05).
Population
Porcine resistance arteries and epicardial conduit coronary arteries (in vitro model)
Comparison
A23187 ionophore and bradykinin vs Comparison between resistance arteries and…
Design
Preclinical
Authors
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Hypothesis-generating for regional endothelial differences; should not yet influence clinical coronary disease management.
Absolute Event Rate: 10.8% vs 17%
p-value: p=<0.05
Porcine resistance arteries express less NOS and produce less nitric oxide than epicardial conduit arteries, contributing to diverse regional vasomotor responses.
Xu et al. (1996) studied this question. Resistance arteries vs. Epicardial conduit coronary arteries was evaluated on Nitric oxide production in response to A23187 (nmol/microgram protein) (p=<0.05). Porcine resistance arteries produced significantly less nitric oxide in response to A23187 compared to epicardial conduit arteries (10.80 vs 17.00 nmol/microgram protein; P<0.05).
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