Key result
Endothelin-1 causes greater coronary artery contractions in female versus male pigs due to intracellular calcium differences.
Population
Sexually mature male and female pigs (in vivo and ex vivo coronary arteries and aortic endothelial cells)
Comparison
Endothelin-1, endothelin-3, and sarafotoxin S6c vs Male vs female pigs, and low- vs high-oestrogen…
Design
Preclinical
Authors
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Sex differences in porcine coronary endothelin-1 reactivity warrant caution extrapolating to humans; hypothesis-generating for sex-specific vasomotor mechanisms.
Gender differences exist in the contractile response of porcine coronary arteries to endothelin-1, likely mediated by differences in intracellular calcium regulation rather than receptor or transcriptional mechanisms.
Miller et al. (1996) studied this question. Endothelin-1 vs. Male pigs was evaluated on Contractions of rings of coronary arteries. Endothelin-1 caused greater contractions in coronary arteries from female pigs compared to male pigs, likely due to differences in the regulation of intracellular calcium.
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