Why the study?
Does exercise training reduce the sensitivity of coronary smooth muscle to endothelin-1 in miniature swine, and is this adaptation gender-dependent?
Population
Male and female miniature swine
Comparison
Exercise training vs Sedentary (Sed) groups
Design
Preclinical
Authors
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May indicate sex-specific coronary ET-1 adaptations to exercise in swine; leaves open translation to human disease.
Does exercise training reduce the sensitivity of coronary smooth muscle to endothelin-1 in miniature swine, and is this adaptation gender-dependent?
Exercise training reduces the contractile sensitivity of coronary arteries to endothelin-1 in male but not female miniature swine, indicating a gender-dependent physiological adaptation.
Jones et al. (1999) studied this question.
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