Why the study?
Does exercise training alter vasoconstrictor responses to ACh, ET-1, KCl, and Bay K 8644 in coronary resistance arteries of female Yucatan miniature swine?
Population
Female Yucatan miniature swine (n=31 total; 16 trained, 15 sedentary)
Comparison
Exercise training on a motor-driven treadmill… vs Sedentary control for 16-20 weeks
Design
Preclinical
Follow-up
16-20 weeks
Authors
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Exercise training does not alter vasoconstrictor responses in this swine model; leaves open whether myogenic adaptations are specific and clinically relevant.
Does exercise training alter vasoconstrictor responses to ACh, ET-1, KCl, and Bay K 8644 in coronary resistance arteries of female Yucatan miniature swine?
Exercise training does not alter receptor-mediated or voltage-gated Ca2+ channel vasoconstrictor responses in porcine coronary resistance arteries, suggesting that previously observed enhanced myogenic reactivity is a specific adaptation.
Laughlin et al. (1998) studied this question.
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