What question did this study set out to answer?

To determine whether chronic exercise training improves endothelium-dependent vasodilation in the pulmonary arteries of swine with coronary artery occlusion.

February 1, 2000Journal of Applied Physiology

Chronic exercise training improves ACh-induced vasorelaxation in pulmonary arteries of pigs

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Why the study?

Does exercise training improve endothelium-dependent vasodilation in pulmonary arteries of pigs with coronary artery occlusion?

Population

Female Yucatan miniature swine with surgically induced coronary artery occlusion (ameroid occluder)

Comparison

Exercise training for 16 weeks vs Sedentary (Sed) pigs

Design

Preclinical

Follow-up

16 weeks

Authors

LJLynelle R. JohnsonUniversity of California, Davis JPJanet L. ParkerUniversity of Georgia MLM. Harold LaughlinUniversity of North Texas

Discussion

Member takes

Implication

Supports exercise benefits on pulmonary vasorelaxation in swine coronary occlusion models; hypothesis-generating with no clinical translation yet.

Key Points

To determine whether chronic exercise training improves endothelium-dependent vasodilation in the pulmonary arteries of swine with coronary artery occlusion.
Female Yucatan miniature swine with surgically induced coronary occlusion via ameroid occluder completed 16 weeks of exercise training or remained sedentary.
Isolated pulmonary artery rings (2- to 3-mm outer diameter) were evaluated for isometric contractile and relaxation responses to pharmacological agonists.
Maximal relaxation to acetylcholine was significantly greater in exercise-trained pigs (61.9 ± 3.5%) compared to sedentary pigs (52.3 ± 3.9%; P < 0.05), while endothelium-independent relaxation to sodium nitroprusside did not differ.
Contractile responses to potassium chloride (80 mM and 10–100 mM isosmotic) and norepinephrine (10⁻⁸ to 10⁻⁴ M) did not differ between sedentary and exercise-trained groups.
Nitric oxide synthase inhibition led to significantly greater suppression of acetylcholine-induced relaxation in exercise-trained arteries (P < 0.05), whereas cyclooxygenase inhibition enhanced relaxation in sedentary arteries.

Structured PICO

Does exercise training improve endothelium-dependent vasodilation in pulmonary arteries of pigs with coronary artery occlusion?

Population

Female Yucatan miniature swine with surgically induced coronary artery occlusion (ameroid occluder)

Intervention

Exercise training for 16 weeks

Comparator

Sedentary (Sed) pigs

Outcome

Endothelium-dependent vasodilation (maximal relaxation to acetylcholine)surrogate

Exercise training enhances endothelium-dependent vasorelaxation in pulmonary arteries of swine with coronary occlusion via increased nitric oxide reliance and reduced prostanoid constrictor production.

Cite This Study

Johnson et al. (2000) studied this question.

synapsesocial.com/papers/6a744a10c2eb6969bf09314c https://doi.org/10.1152/jappl.2000.88.2.443

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Implication

Supports exercise benefits on pulmonary vasorelaxation in swine coronary occlusion models; hypothesis-generating with no clinical translation yet.

Chronic exercise training improves ACh-induced vasorelaxation in pulmonary arteries of pigs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Chronic exercise training improves ACh-induced vasorelaxation in pulmonary arteries of pigs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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