Why the study?
Are there sex differences in endothelial function and the role of H2O2 and gap junctions in porcine coronary arteries?
Population
Male and female porcine coronary arteries (PCAs)
Comparison
Bradykinin-induced vasorelaxation in the… vs Male vs. female PCAs
Design
Preclinical
Authors
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May inform sex-specific coronary endothelial mechanisms; hypothesis-generating and leaves open human translation.
Are there sex differences in endothelial function and the role of H2O2 and gap junctions in porcine coronary arteries?
Endothelium-derived hyperpolarization and H2O2 play a more prominent role in endothelium-dependent vasorelaxation in female compared to male porcine coronary arteries, potentially explaining vascular protection in premenopausal women.
Wong et al. (2014) studied this question.
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