April 1, 1992AJP Heart and Circulatory Physiology
Vasomotor properties of porcine endocardial and epicardial microvessels
Key result
Endocardial microvessels were significantly more sensitive to adenosine than epicardial microvessels (ED50 -6.59 vs -5.66, P<0.001).
Population
Porcine endocardial microvessels from the anterior papillary muscle and epicardial microvessels of similar…
Comparison
Exposure to neurohumoral substances including… vs Comparison between endocardial and epicardial…
Design
Preclinical
Authors
Discussion
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Implication
Endocardial adenosine hypersensitivity may shape subendocardial perfusion gradients; leaves open translation to human physiology or therapy.
Structured PICO
P
Population
Porcine endocardial and epicardial microvessels studied in vitro to compare sensitivity to neurohumoral substances.
I
Intervention
Exposure to neurohumoral substances including bradykinin, ADP, A23187, nitroprusside, adenosine, and forskolin
C
Comparator
Comparison between endocardial and epicardial microvessels
O
Outcome
Vasorelaxation sensitivity (ED50) to neurohumoral substancessurrogate
Main Result
Absolute Event Rate: -6.59% vs -5.66%
p-value: p=<0.001
Endocardial microvessels exhibit enhanced sensitivity to adenosine compared to epicardial microvessels, which may play a role in regulating myocardial perfusion in subendocardial layers.
Cite This Study
Quillen et al. (1992) studied this question. Adenosine and other vasodilators vs. Epicardial microvessels was evaluated on Sensitivity to adenosine (ED50) (p=<0.001). Endocardial microvessels were significantly more sensitive to adenosine than epicardial microvessels (ED50 -6.59 vs -5.66, P<0.001).